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Actalipid (Simvastatin)
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Simvastatin

We aimed to assess the use of Actalipid for the improvement of cognitive and behavioural deficits in children with neurofibromatosis type 1 for 12 months. Furthermore, Actalipid, an inhibitor of cholesterol biosynthesis, acted synergistically with both heterocyclic compounds to clear PrPSc.

Other names for this medication:
Simvastatin, Zocor, Actalipid, Lipex, Lipinorm, Lodales, Simcard, Simgal, Simvastatina, Simvor, Sinvacor, Sivastin, Vasilip, Zeid, Zocord, Zosta, Zostin,

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Actalipid is used together with a proper diet to treat high cholesterol and triglyceride (fat) levels in the blood. This medicine may help prevent medical problems (eg, heart attacks, strokes) caused by clogged blood vessels. Actalipid may also be used to prevent certain types of heart problems in patients with risk factors for heart problems.

Actalipid belongs to the group of medicines called HMG-CoA reductase inhibitors, or statins. It works to reduce the amount of cholesterol in the blood by blocking an enzyme that is needed to make cholesterol.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet
  • Suspension

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The REMAP study will demonstrate the ability of integrated 18F-FDG PET-MRI to provide a more personalised approach to therapy. EEG characteristics were extracted from intracranial rhinal and hippocampal depth recordings in 31 epilepsy patients performing a continuous word recognition paradigm. Bacterial culture was performed using a swab from the middle nasal meatus under endoscopic control in 72 patients with CRSwNP, 25 patients with CRSsNP and 59 healthy controls. First record of the genus Lumahyphes Molineri, 2004 (Ephemeroptera: Leptohyphidae) from Brazil with description of a new species. Cells at the interface between these two arms of the immune response are thus critical to provide full engagement of host defense.

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Development of a sensitive and robust online dual column liquid chromatography-tandem mass spectrometry method for the analysis of natural and synthetic estrogens and their conjugates in river water and wastewater. This measure reveals connections between different regions by exploiting statistical dependencies within multichannel recordings.

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Coil migration after endovascular coil occlusion of internal carotid artery pseudoaneurysms within the sphenoid sinus. WILL THE ADULT FIREFLY LUMINESCE IF ITS LARVAL ORGANS ARE ENTIRELY REMOVED? Surgical replacement of the aortic valve is an effective treatment modality in patients with degenerative and calcific aortic stenosis. Reflecting the resected portion of the proximal jejunum behind the mesenteric vessels during a pancreaticoduodenectomy (Whipple) procedure can be a challenging maneuver. Magic and Misdirection: The Influence of Social Cues on the Allocation of Visual Attention While Watching a Cups-and-Balls Routine.

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Predictors of 30-day mortality and hospital costs in patients with ventilator-associated pneumonia attributed to potentially antibiotic-resistant gram-negative bacteria. We tested whether opioids provoke dopamine release and its relationship to the subjective experience.

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Post-perceptual processing during the attentional blink is modulated by inter-trial task expectancies. Prompted by results obtained from improved fixation procedures and serial sectioning, we question the basis for the theory of secretory cycles. These new mutations, along with eight previously identified mutations, were distributed throughout N651, indicating that each subdomain has an important function. Selective recognition of DNA signals was achieved by hybridizing the DNA signals with the oligonucleotide lipid embedded in the liposome. The more rapid rate, equivalent to a maximum vertical accretion of 3 to 5 millimeters per year, places an upper limit on the potential of modern coral reef communities to create a significant vertical structure on a rising sea.

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Estradiol treatment increases the responsiveness of adrenal cortex of Oophorectomized female rats. Nursing diagnoses among kidney transplant recipients: evidence from clinical practice. We evaluated clinical profiles from included patients from January 2005 to July 2009 and we prospectively recruited additional patients from August 2009 to July 2011. Infectious HSV-1 has been found in mouse denervated tissues and in tissues with negative cultures from the corresponding ganglion. This study suggests that our novel MPC algorithm can safely and effectively control glucose overnight, also when CL control is initiated during hyperglycemia.

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Women aged 18-54 years undergoing any of the previously mentioned leiomyoma procedures between 2000 and 2013 were included. Differentiation of K562 with butyric acid, a CML cell line, decreased BCL11A mRNA levels. The Episure Autodetect Syringe is currently indicated by the US Food and Drug Administration for use with an epidural needle for the verification for needle tip placement in the epidural space. This study examines social support effect on stress and adaptation through the mediating effect of control. The medial belly originated from the common flexor tendon from the medial condyle of the humerus and continued as a thin tendon at the middle of the forearm to insert onto the fifth digit.

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Intra-abdominal pressure measurement may be used as a predictor of intestinal strangulation in patients presenting acute abdominal compartment syndrome secondary to complicated hernia. Base extrusion is a major structural feature at the junction between B- and Z-DNA (the B-Z junction) where a base pair is broken, and the two bases are extruded from the double helix. Influence of ProTaper finishing files and sodium hypochlorite on cleaning and shaping of mandibuldar central incisors--a histological analysis. Expression by glia did not appear to contribute significantly to detectable levels of either alpha 1-tubulin or beta II-tubulin mRNA.

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Commentary on Viewpoint: Exercise and cardiovascular risk reduction: time to update the rationale for exercise? There is however still much left to understand to make this more widely applicable, and the extreme cost of these therapies is a serious concern.

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In addition, solubility of nanocurcumin is also believed to be a crucial factor behind its successful antimicrobial activity. Comparative study of the closed reduction percutaneous cannulated screw fixation and open reduction palmar locking plate fixation in the treatment of AO type A2 distal radius fractures. We included consecutive patients of all ages with OA caused by lesions affecting the visual pathways who were referred over a 9-month period (November 2013 to July 2014). Dermoscopic examination of 28 cases of nodular hidradenomas was performed to evaluate specific dermoscopic criteria and patterns. This finding can be explained by the presence of microscopic configurational inhomogeneity in water-methanol mixtures.

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Identification and quantitation of new glutamic acid derivatives in soy sauce by UPLC/MS/MS. elegans has previously been shown to improve protein homeostasis and extend lifespan, possibly due to reallocation of resources to somatic cells. The results are useful in the selection of candidates for DREZotomy and prediction of surgical outcome. Accordingly, the expression of a Tat construct containing mutations in the basic region (49-57aa), which is responsible for the interaction with PKR, favored neither parasite growth nor IL-10 expression in infected macrophages.

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Recruitment was conducted from February 2010 through August 2013, and participation occurred within 2 Department of Veterans Affairs hospitals. Conversely, directing the cannula tip toward the aortic root generated slower and less turbulent flow in the transverse aortic arch despite high velocity and turbulence and nonlinear streamlines in the ascending aorta. Amorphous Phosphorus-Incorporated Cobalt Molybdenum Sulfide on Carbon Cloth: An Efficient and Stable Electrocatalyst for Enhanced Overall Water Splitting over Entire pH Values. Geranylgeranylacetone (GGA), a clinically used antiulcer drug, increased expression of HSP70 in the small intestine and suppressed indomethacin-induced lesions of the small intestines in wild-type mice.

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CT evaluation of locoregional spread of carcinoma of the gallbladder The binding constants for TB12 were 2.10(7) M-1 with ML1 toxin, and more than 10(6) M-1 with ML2 and ML3. Transvaginal ultrasound and hysteroscopy were used for diagnosis, and conservative therapy with methotrexate and hysteroscopy to treat the patient.

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As a consequence of industrialization, the 19th century was shaped by the impoverishment of a large part of the population. Leaching of additives may occur from the intact material, as they are often not covalently bound to the polymer backbone, but is greatly enhanced when micro-sized plastic particles have been formed. Limitations of conventional endobronchial ultrasound (C-EBUS) bronchoscopes include the inability to perform a complete airway inspection, low definition optics, and limited maneuverability. Coping processes relevant to posttraumatic growth: an evidence-based review. These vectors had two potential drawbacks: suboptimal stringency (e.g.

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A 24-year-old man developed abdominal carcinomatosis from signet cell carcinoma of the rectum. In this article, we consider this modeling framework and focus particularly on the assessment of the predictive ability of the longitudinal marker for the time-to-event outcome. To date, there is no dietary reference intake (DRI) for EPA and DHA, although many international authorities and expert groups have issued dietary recommendations for them. The reason for this is the instability of the vertebral body despite the injection of the PMMA cement.

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Assessment of hydroalcoholic extract of seeds and leaves of Moringa peregrina on ileum spasm. Pharmacologic inhibition of BMI-1 in patient-derived cells significantly decreased colony formation in vitro and attenuated tumor initiation in vivo, thereby functionally diminishing the frequency of TICs, particularly in cells resistant to proliferation- and androgen receptor-directed therapies, without toxic effects on normal tissues.

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During the task, the participants were exposed to either left anodal/right cathodal GVS, right anodal/left cathodal GVS, or sham stimulation (control condition). Stress Response and Habituation to Motorboat Noise in Two Coastal Fish Species in the Bothnian Sea. Low-complexity (LC) domains regulate the aggregation and phase transition of proteins in a modification-dependent manner. This paper discusses how empirical studies have generally tackled the problem of movement artifact by adopting alternative paradigms which avoid recording during actual physical exertion.

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We found 6 systematic reviews, RCTs or observational studies that met our inclusion criteria.We performed a GRADE evaluation of the quality of evidence for interventions. Patients having low sVAP-1 levels had significantly poorer prognosis relative to patients having elevated sVAP-1 in all or stages I-III gastric cancer patients, respectively. Interestingly, differentiation is mediated by RARgamma, but not by RARalpha or RARbeta, suggesting that RARgamma possesses unique and uncharacterized molecular properties.

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However, combination therapy of rifampin and isoniazid with NAC was not being effective. Preoperative inflammation-based factors including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio, gamma-glutamyl transferase/alanine aminotransferase ratio, aspartate aminotransferase/platelet ratio index (APRI) and prognostic nutritional index together with other clinicopathologic parameters were evaluated by univariate analysis and multivariate analysis to identify independent prognostic factors. A punch biopsy was done from a representative follicular lesion to evaluate the pathological changes.

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To compare the use of acceleration-dependent and velocity-dependent flow-preparation for non-contrast-enhanced magnetic resonance angiography (NCE-MRA), investigating both image quality and the ability to discriminate between arteries and veins. Effect of pressure on echocardiographic videodensity from sonicated albumin: an in vitro model. Moreover, a less significant weight gain was noticed in animals i.p.- and p.o.-treated with 100mg/kg/day during the 28-day period of treatment, which, upon comparison with the three other groups, induced a body weight gap that was maintained throughout the experiment. We propose that these hypothalamic changes underlie the well-established relationship between sleep loss and several diseases such as metabolic disorders, stress and depression and that sufficient sleep is vital for autonomic functions controlled by the hypothalamus. The peroxidase activity resulted from a single secreted class III peroxidase (Prx34) which belonged to a P.

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As a number of these processes also determine cellular survival, these novel agents can work to lower the cytotoxic threshold for conventional drugs. There have been important advances in our understanding of normal peritoneal healing and the pathophysiology of adhesions. Chronic total occlusion percutaneous coronary intervention (CTO PCI) procedural planning involves much thought and deliberation before one actually attempts to cross the CTO lesion in the cardiac catheterization laboratory. By contrast, overexpression of xlnR under the control of the Aspergillus nidulans gpdA promoter did not significantly increase xylanase activity, suggesting that XlnR is regulated not only at the transcriptional but also at the post-translational level. Lack of a treatment specific effect is discussed in relation to the placebo and patient provider interactions in manual therapies.

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We present 52 patients with AVMs, analysing Neurological Exam, Ct, Irm and Brain Arteriography. As a critical downstream mediator of PI3K signaling, mTOR is important for lymphocyte development and function of mature T and B-cells. Treatment with antioxidants impaired the AA-induced apoptosis and down-regulation of GLI1 and NFATc1 activation, indicating that NFATc1 activation and GLI1 repression require the generation of reactive oxygen species.

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This study aims to compare self-reported general-health status in patients before and after prosthodontic treatment. Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway. The parturition is characterized by a dramatic loss of most of the glycosaminoglycans. Evidence-based practice-focused interactive teaching strategy: a controlled study. To investigate the clinical manifestations of autoimmune thyroiditis (AIT) leading to referral in children and adolescents, in addition to disease course and long-term outcome.

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Influence of cell shape, inhomogeneities and diffusion barriers in cell polarization models. Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells. A linear decline in fixation times occurred as the object distance increased from 30 to 90 centimeters with the real size and the angular size of the object held constant (experiment 2). We address this issue in our current study by analyzing nucleotide composition in genome regions between known replication origins, with an aim to reveal any adenine to guanine deamination gradients. Treatment of the disorder is commonly by way of prescription medication.

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Our results suggest that graphical models based on integrative genomic data are computationally efficient, work well with small samples, and can describe complex interactions among genes and polymorphisms that could not be identified by pair-wise association testing. The combination of favorable organ biodistribution and myocardial uptake with rapid liver clearance makes Tc-99m-N-MPO a very promising myocardial perfusion radiotracer worthy of further evaluation in various preclinical animal models. Molecular neural network devices based on non-linear dynamic media: basic primitive information processing operations. We report a 3 years old boy with a medullary astrocytoma and ventriculo-peritoneal shunt placement who demonstrated intermittent ventriculomegaly during a single MRI scan. Associations of maternal 25-hydroxyvitamin D in pregnancy with offspring cardiovascular risk factors in childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children.

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KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma. This study enrolled 165 stable COPD patients who completed the CAT between April 2011 and February 2012.

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Unicompartmental Knee Arthroplasty Achieves Greater Flexion With No Difference in Functional Outcome, Quality of Life, and Satisfaction vs Total Knee Arthroplasty in Patients Younger Than 55 Years. Re: Adjuvant treatment of high-risk, radically resected gastric cancer patients with 5-fluorouracil, leucovorin, cisplatin, and epidoxorubicin in a randomized controlled trial. Our results indicate that CMD shows very similar performance to RPMD. Concentration of lipids and lipoproteins in serum of women with pregnancy induced hypertension Iron deficiency anemia was the rule, often requiring blood transfusion.

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The feasibility study on 3-dimensional fluorescent x-ray computed tomography using the pinhole effect for biomedical applications. Human hepatoma cell line (HepG2) cells were cultured on the quartz crystal through a collagen film.

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Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche. Some microbial, chemical and sensorial properties of gamma irradiated sesame (Sesamum indicum L.) seeds. Plagiocephaly: differential diagnosis based on endocranial morphology.

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The extent to which cortical damage itself or cortical disconnection by white matter fiber pathway disruption contribute to deficits in emotion, cognition, and behavior can be investigated with in vivo structural neuroimaging and diffusion tensor imaging (DTI)-based quantitative fiber tracking. Scattering through fluids: speckle size measurement and Monte Carlo simulations close to and into the multiple scattering.

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Intrarenal activation of renin angiotensin system in the development of cyclosporine A induced chronic nephrotoxicity. Effective diabetes mellitus management requires to maintain blood glucose levels in a narrow range between hyperglycemia causing late complications, and danger of severe hypoglycemia. It summarises current concepts of the mechanisms for the development of heat illness. All of the three patients died of metastatic disease at 5, 7, and 13 months.

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Sequential changes in insulin-like growth factor I (IGF-I) and IGF-binding proteins in children with end-stage liver disease before and after successful orthotopic liver transplantation. IL should be suspected in any patient with a mobile abdominal mass and surgery is required immediately after discovery of the tumor.

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Atrial fibrillation and central nervous complications in liver transplanted hereditary transthyretin amyloidosis patients. The sequence represents a novel structure with no significant homology to any previously published sequence. A Novel Approach to Assess Motor Outcome of Deep Brain Stimulation Effects in the Hemiparkinsonian Rat: Staircase and Cylinder Test. The basis for the treatment of low flow diclomax 25 mg dosage priapism includes treating sickle cell disease and the usage of intracavernous adrenergic agents as necessary. CpG island methylator phenotype (CIMP) was tested by methylation-specific PCR.

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pylori positive antral gastritis with normal body histology, and H. A novel inhibitor of bupropion xl 450 mg inducible nitric oxide synthase, ONO-1714, does not ameliorate hypoxia-induced pulmonary hypertension in rats. Moreover, several studies have been suggesting a protective effect of magnesium on the vascular calcification. These effects have led to possible implications in the pathophysiology of immune-mediated diseases including multiple sclerosis and inflammatory bowel disease (IBD).

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Most of them associate gene therapy and chemotherapy or radiochemotherapy. The prolactin (PRL) gene is known to be expressed not only in the anterior pituitary but also in the decidualized human endometrium. The induction of the male sexual organ primordia (antheridial hyphae) by the steroid hormone antheridiol in the water mold Achlya ambisexualis requires both transcription and translation. iIGF-I was highest in first colostrum and then dramatically diclofenac ratiopharm gel 50g decreased within the first 2 days of lactation. Axisymmetric turbulent wakes with new nonequilibrium similarity scalings.

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A 64-year-old man with history of prostate adenocarcinoma underwent radical prostatectomy in 2003. Percutaneous radiofrequency ablation (RFA) for small renal tumors has been reported to be effective in patients with poor surgical status. Modifications in the lamivudina zidovudina vademecum toothpaste basic structure generated in vivo activity and thus different topically active compounds were discovered.

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Alterations in lung histomorphology correlated with the level of pp-MLC. Ranking nuclear aglan 15 mg zastrzyki b12 and radiological terrorism scenarios: the Italian case. To evaluate corrected thrombolysis in myocardial infarction (TIMI) frame count (CTFC) in patients with angiographically normal coronary arteries and diabetes mellitus, a condition known to be associated with microvascular dysfunction.

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We present the Europe PMC literature component of Open Targets - a target validation platform that integrates various evidence to aid drug target identification and validation. Additional etiologies include trigonal process fracture, flexor amovin azithromycin and alcohol hallucis longus tenosynovitis, posterior tibiotalar impingement by bone block, and intraarticular loose bodies. Prognostic factors for trabeculectomy failure in a Cuban population. Moreover, it is now clear that OCD is a neurobehavioral disorder involving dysregulation in links between cortical and subcortical circuitry that is substantially influenced by serotonergic neurotransmission.

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There was a more pronounced effect on TG-rich lipoproteins, particularly in ApoE2/2 (a feature of type III dysbetalipoproteinemia), and non-high-density lipoprotein (HDL) cholesterol deplatt a 75 drug addiction in ApoE4/4. Altering MEOWS trigger parameters may improve the accuracy of MEOWS in predicting ICU admission. To examine trends in the incidence of skin infections in relation to trends in dispensed prescriptions for flucloxacillin, topical fusidic acid, mupirocin, and corticosteroids with fusidic acid.

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They most likely represent a distinct group of malignant amlodipine besylate side effects 10mg tumors among the canine round cell tumors. Chronic obstructive pulmonary disease (COPD) exacerbations are associated with lung function decline, lower quality of life, and increased mortality, and can be prevented by pharmacological treatment and rehabilitation.

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147 general practices (annual list size over 1 million) across the UK. A Cartesian subsampling scheme is proposed incorporating the idea of PF acquisition and variable-density Poisson Disc (vdPD) subsampling by redistributing the sampling space onto a smaller region aiming to increase k-space sampling density for a given acceleration factor. The adjustment of anticancer-drug delivery to the circadian-timing system (chronotherapeutics) has allowed to reduce fiche information therapeutique imiject five-fold the incidence of severe adverse events as compared to constant rate infusion or wrongly-timed chronomodulated delivery in cancer patients. Both ellagitannins and flavonoids effectively prevented lipid peroxidation and protein oxidation in mitochondria.

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This article provides an overview of up-to-date techniques and methodology for enhanced recovery, including an overview of value-based care, delivery, and the evidence base supporting enhanced recovery after surgery. Sclerotic Therapy in Practice-Part IV: The Injection Treatment of Hydrocele and Some Other Conditions. CT scan of adrenal glands was performed with the perfusion of non-ionic contrast medium Ultravist. Selective effects of tea extract and its phenolic compounds on human omnexel dose peripheral blood mononuclear cell cytokine secretions. In the future, these same tools, combined with computational modeling and artificial neural network analyses, may also be used to predict individual clinical responses to drugs in a personalized medicine approach.