Ezetimibe and Atorva combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels. It is also used to treat a condition called homozygous familial hypercholesterolemia (HoFH).

Ezetimibe is a cholesterol absorption inhibitor and Atorva is an HMG-CoA reductase inhibitor, or statin. These medicines will reduce the absorption of cholesterol from foods and the production of cholesterol in your body.

This medicine was available only with your doctor's prescription.

The Atorva/ezetimibe combination (Liptruzet(R)) was withdrawn from the United States market on June 2, 2015.

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At 1 month follow-up, in 10 patients of 12, the Valsalva manoeuvre was negative, same result at the 3rd month follow-up, although in 11 of 12 patients. The antitumor effects were confirmed by in vitro cellular reactive oxygen species detection and cytotoxicity assays, and in vivo in a xenograft tumor model, with no damage to body organs. In this work, besides the well-known rank correlation index, two new similarity indices have been defined and applied to compute the similarity matrix related to the Apulian meteo-climatic monitoring network.

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Cerebellar ptosis must be considered in cases of delayed symptoms after large suboccipital craniectomy regardless of pathology. The nuclear disease protein enhanced polyQ toxicity by binding to heat shock protein (hsp) gene promoter and abolished hsp gene induction. Ocular diseases affecting retina, such as diabetic retinopathy (DR), age-related macular degeneration (AMD) and glaucoma are the major causes of blindness, and their treatment is still a challenge due to the special structure of the eye. Simple phenols may be useful for revealing the medium-term effects of prescribed burning.

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Evolution of sociality by natural selection on variances in reproductive fitness: evidence from a social bee. Fondaparinux is a synthetic pentasaccharide, which binds to antithrombin, thereby indirectly inhibiting factor Xa. In contrast, intra-peritoneal and intra-venous injections in mice resulted in death or euthanasia.

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Those with a clinical diagnosis of depression, or a lifetime diagnosis of bipolar disorder or psychosis on the SCID will be excluded. Aerosol therapy through high flow nasal cannula in pediatric patients. In a prospective double-blind crossover study, electrodes were bilaterally implanted in the STN and GPi of 12 patients with focal, multifocal, or generalized dystonia. A reduced dexamethasone related increase of antithrombin and protein S, and subsequent decline below normal levels after introduction of asparaginase, may result in a hypercoagulable state, contributing to development of symptomatic osteonecrosis. Ambulatory patients from a large university out-patient clinic were studied (323 patients with Type 1, 906 patients with Type 2 diabetes).

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Furthermore, a medium conditioned by CD16(158V)/NK-92 cells also upregulated the expression of TP mRNA in NCI-N87 cells. Bone marrow derived mesenchymal stem cells (BMMSCs) is a valid, definitive candidate for repair of damaged tissues in degenerative disorders in general and neurological diseases in particular. Correlation tests, and simple and multiple regression analyses were performed to determine the relationship between the visual CT abnormalities, physiologic parameters, and autoantibody titers.

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Identification of vaccine human papillomavirus genotypes in squamous intraepithelial lesions (CIN2-3). The rational of this study was to determine its clinico-hematological profile along with risk stratification in Pakistan patients. Biological information curated for these data objects includes disease associations, phenotypes, pathways, molecular functions, biological processes and cellular components. Centenary of the death of Elie Metchnikoff: a visionary and an outstanding team leader.

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Prostatic and penile tissue was evaluated for general histology (hematoxylin-eosin). Further, our results suggest that 5-HT release in DRN projection regions augments defeat-induced changes in social behavior. Coffee cultivation is widespread in the tropics, and its management is conducted along a gradient of intensity, which ranges from monoculture (i.e., no shade, high inputs) to polyculture (shade overstory retained, fewer inputs). The optimum conditions of the reaction and influencing factors were investigated. Mice were inoculated and then challenged with parenteral toxin A.

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In addition to a thorough case description, the literature concerning this entity is reviewed and discussed. Has mandatory folic acid supplementation of foods increased the risk of asthma and allergic disease?

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These alterations may be more pronounced in the malignant than in the benign phase of hypertension. Structural drivers of vulnerability to zoonotic disease in Africa. A 1.8 kb cDNA fragment of SHP-1 gene was obtained from MCF-7 cells and successfully inserted into the pLNCX2. A BaSiC tool for background and shading correction of optical microscopy images. These data revealed a novel mechanism by which Gp1 mGluR and FMRP mediate protein translation and neural network activity, potentially through de-repressing Mdm2.

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Chemiluminescent and fluorescent hydrophilic, hydrophobic and amphyphilic molecular probes were used to: (i) ensure penetration of probes into skin, (ii) enhance the intensity of BP emission, (iii) shorten time and (iv) obtain information about mechanisms of biophotons generation in EAP-sensitive points and channels. In the in vivo assay, (15R)-PGE2 (1) and (15R)-O-Ac-PGA2 (3) showed anti-inflammatory activity, as well as in vitro inhibition of elastase release from PMNs. Patients need more specific information about taking pain medication on a specified schedule to control pain.

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Normally, these hydrolyses are carried out conveniently with trifluoroacetic acid (TFA) at high temperatures for long periods of time, for example, in 4M TFA at 100 degrees C for 5h in a heating block. Differential tumor expression of inhibitor of differentiation-1 in prostate cancer patients with extreme clinical phenotypes and prognostic implications. An overview of adoptive transfer of lymphocytes, tumor infiltrating lymphocytes and dendritic cell therapies is provided.

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A retrospective chart review was performed for 71 consecutive patients who underwent robotic low anterior resection (LAR) or abdominoperineal resection (APR) for rectal adenocarcinoma between 2010 and 2014. The experimental results were applied to suggest a hypothesis and a mathematical model describing the hydrogen sulfide oxidation pathway in a matrix of corroded concrete. The assessment of epiphytic yeast diversity in sugarcane phyllosphere in Thailand by culture-independent method.

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Meanwhile, the second expansion strategy achieved a trade-off between the first and third strategies, leading to acceptable vessel stress and stent apposition. The importance of the study lies in the identification of specific psychological factors for intervention in the psychological treatment of pain. GU in patients receiving chemotherapy, dyspeptic syndrome is characterized by severe, advanced stage of CG on the background of relatively low severity of CG in accordance with the classification of OLGA (2008).

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The groups were well matched for age, abdominal injury scores, and admission vital signs. Distances from the anal verge to the distal and proximal edges of the sphincter, puborectalis and levator muscles were measured in 12 patients using morphological features on magnetic resonance images.

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The presence of foci of dysplasia in one case of SSA supports the hypothesis that these polyps have a carcinogenetic potential and should have the same clinical follow-up as traditional adenomas. Most operations were performed making only two incisions, in some cases under awake epidural anaesthesia. Here we describe a general strategy based on template pyrolysis for converting conventional covalent organic frameworks into high-performance carbons, which combines conductivity, microporosity and heteroatom density, thus casting a distinct contrast to those obtained upon direct pyrolysis.

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Once transferred those with a LOMT had similar rates of cardiac arrest, MET activation and unplanned ICU admission, but higher mortality. Bacillus thuringiensis (Bt) is a unique bacterium in that it shares a common place with a number of chemical compounds which are used commercially to control insects important to agriculture and public health. Germ-line APC analysis showed a C deletion at codon 1460 resulting in a stop codon.

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These findings suggest that the exon 3 Tyr113His and exon 4 His139Arg polymorphisms of EPHXI may be associated with a increased risk of lung cancer and a worse prognosis. As nature shows such elegant examples of multiblock molecules exerting sophisticated functions, synthetic multiblock molecules and copolymers have gained increasing attention as emerging structural motifs for realizing unique properties and functions.

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Olfactory neuroblastoma following treatment for pituitary adenoma. Three of the seven patients underwent simultaneous subtotal resection of recurrent tumor located in the fourth ventricle or cerebellum, and one patient underwent simultaneous tumor biopsy. All nurses and health care professionals are accountable for their clinical practice and are required to be consumers of research ( 1 ).

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To investigate patient experience of CT colonography (CTC) and colonoscopy in a national screening programme. We systematically reviewed the literature for national and international interventions that have successfully increased HPV vaccine uptake. In order to identify active mRNA in bovine oocytes, we sought to develop a method of isolating very small amounts of polyribosome mRNA. In light of these results, we recommend that neck dissection for primary oral squamous cell cancer always include the region of the carotid bifurcation, regardless of the above mentioned associated patient and tumor factors.

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Behavioral economic laboratory assessments, including operant self-administration, choice tasks and purchase tasks, can be used generate behavioral economic data on the effect of price and other constraints on tobacco product consumption. Development of an arthroscopic ultrasound probe for assessment of articular cartilage degeneration.

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Eighteen percent of all cases (6/34) of idiopathic nonimmune hydrops fetalis contained B19 deoxyribonucleic acid. Furthermore, we extended our observations to cerebral vessels, demonstrating that tumor necrosis factor-alpha triggered this mechanism on the basilar artery.

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The authors argue that these perceptions are motivated by the desire for positive task relationships. Depressive Symptoms: The Interaction between Rumination and Self-Reported Insomnia. TM has been used to track info on the clinical status of heart failure patients treated by ICD and/or cardiac resynchronisation therapy defibrillator (CRT-D).

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The levels of cortisol and white blood cell count were decreased, significantly at Week 8, and the levels of pulse rate were significantly decreased at Week 4 from baseline. A structural and dynamic investigation of the inhibition of catalase by nitric oxide. Nursing students who regarded nursing as a lifelong career exhibited stronger critical thinking disposition than did students who considered nursing to be a temporary or premarital job.

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The sequences of Arabidopsis GA-INSENSITIVE RNA constitute the motifs that are necessary and sufficient for RNA long-distance trafficking. One hundred and seventy-six patients (68 men and 108 women), with ages ranged from 6 to 83 years, were randomly recruited. Establishing a group practice: here are some reasons why you should consider it. CFD provides arbitrarily high resolution, but its accuracy hinges on model assumptions, while velocity fields measured with PC-MRI generally do not satisfy the equations of fluid dynamics, provide limited resolution, and suffer from partial volume effects.

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During the photoinhibitory treatment the D1 protein was dephosphorylated in both types of chloroplasts but it was rapidly degraded only in the bundle sheath chloroplasts. It has been shown that crown galls can be utilized as a culture system to produce secondary metabolites. Endorectal 1H magnetic resonance spectroscopy can characterize metabolic differences between the normal and malignant prostate.

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The total systemic exposure of 99-411 increased when administered with either lumefantrine or piperaquine. Consultation rate was high in tuberculosis, asthma, hypertension and diabetes. Value of imaging methods in radiotherapy of invasive breast carcinoma

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LMO2, HGAL, STMN1 and AID, but not MNDA, are discriminant for the recognition between CFL and CMZL. Consistent with this, central insulin decreased hypothalamic NPY and AgRP and increased POMC mRNA expression.

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Clinical molybdenum x-ray spectrum measurements were also performed by using a pinhole collimator and a custom alignment device. The combined effects of BDE47 and BaP on oxidatively generated DNA damage in L02 cells and the possible molecular mechanism.

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In this study, we have investigated the regulation of vaspin gene expression in rat white adipose tissue (WAT) in different physiological (nutritional status, pregnancy, age and gender) and pathophysiological (gonadectomy, thyroid status and growth hormone deficiency) settings known to be associated with energy homeostasis and alterations in insulin sensitivity. The testicular differentiation in male channel catfish normally starts between 90 and 102 days postfertilization (dpf), while the ovarian differentiation starts early from 19 dpf.

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Synthetic receptors for the differentiation of phosphorylated peptides with nanomolar affinities. The obtained MR image contrasts are similar to a variety of biological tissues, which can contribute to optimization of imaging techniques with respect to specific clinical questions. Treatment of primary or secondary episodes in the immunocompetent host is therefore directed toward more rapid resolution of initial and recurrent episodes, thereby limiting the impact of the infections. This study sought to evaluate the importance of neural adaptations by comparing the repeated bout effect on muscle injury caused by voluntary and electrically stimulated eccentric exercise.

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The GroEL-GroES chaperone pair had no effect on protein production. Continued work in identifying alterations that contribute to the transformation, progression, and metastasis of MPNST coupled with longitudinal follow-up, biobanking, and data sharing is needed to develop prognostic biomarkers and effective prevention and therapeutic strategies for MPNST. Structure of Rat Lungs after Administration of Magnetomicelles Based on the Carbon-Coated Iron Nanoparticles.

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Emphasis is placed on both high resolution diffractive components such as gratings and zone plates and multidimensional reflective diffracting structures using multilayer interference mirrors. Exploring perceived control and self-rated health in re-admissions among younger adults: A retrospective study. Female size increases rapidly with host size, so females may have more to gain than males by remaining in and growing mutually with small hosts. The dogs with NME had the highest levels of anti-GFAP autoantibodies. The knowledge about various forms of disease manifestation may contribute to an early diagnosis and timely initiation of treatment, which may prevent devastating irreversible impairment.

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Recent studies suggest the importance of optimal and combined provision of energy and protein to optimize clinical outcome. Granular cell tumour of the breast: case series and review of the literature.

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To complete a systematic survey of the literature, 19 databases and 4 individual open-access journals were employed. Expanding the definition of class 3 inteins and their proposed phage origin.

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In this work, moisture sorption-desorption characteristics and thermodynamic properties of CDP have been investigated. albicans, whereas at subinhibitory concentrations it reduced its virulence by preventing the adherence ability and germ tube formation. In the model, hypothetical chemical toxicity targeted different vital individual-level processes: reproduction, survival, feeding rate, or somatic growth rate. Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis.

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The data indicate that dl-THP decreases both arterial pressure and heart rate through a serotonergic release process in the hypothalamus. The particle size distribution was measured using a cascade impactor. Twenty-two postmenopausal women with biopsy-proven NAFLD and 18 matched controls were recruited. It is unclear whether race/ethnicity influences survival for acute critical illnesses. It was carried out at the MS Kashani Center affiliated to the Isfahan University of Medical Sciences, in 2013.

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Cognitive remediation (REM) is a behavioral intervention that holds promise for improving cognition and functioning in schizophrenia, however the extent to which it affects thalamo-prefrontal connections has not been researched. The data reported in this study can be used as normal values for the DWS of the left ventricle determined by M-mode echocardiography. Recent work has shown that cochlear neurons are actually more vulnerable to noise, and even after exposures causing only temporary threshold elevation and no loss of hair cells, there is a rapid and irreversible loss of synaptic connections between cochlear neurons and hair cells followed by a slow degeneration of cochlear nerve cell bodies and central axons. We present a case of SCCP with SIADH that was successfully treated with radiotherapy in the metastatic lymphnodes and prostate. Here, we report a male-to-female sexual transmission of ZIKV in Germany in April 2016, following travel to Puerto Rico of the male patient, demonstrated by subsequent seroconversions and molecular identification of identical virus sequences from both patients.

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Pain score levels were collected by using an 11-point scoring system. Memory was assessed by the recall of 15 previously presented objects. Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): gill injury, oxidative stress, and other physiological effects. They used Poisson regression analyses to determine the overall association between antidepressant prescription rates and suicide rates, adjusted for sex and age, during the periods preceding and immediately following the public health warnings.