TBARS formation in rat liver microsomes was suppressed by diethyldithiocarbamate (a specific inhibitor of cytochrome P450 (CYP)2E1) and Cambia (a specific inhibitor of CYP2C11). The techniques have been hyphenated and used to study tablets containing Cambia sodium and HPMC (hydroxypropyl methylcellulose) in different dissolution media that influence the solubility of the drug.
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