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Imiject (Sumatriptan)
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Sumatriptan

Initial concerns about the coronary side-effect potential of the anti-migraine drug Imiject and second-generation triptans initiated cranioselectivity studies using proximal human coronary arteries. However, the potency of eletriptan and Imiject was higher in meningeal artery than in coronary artery (86-fold for eletriptan and 30-fold for Imiject) or saphenous vein (66- and 25-fold).

Other names for this medication:
Sumatriptan, Imitrex, Amigrenex, Amigrenin, Cinie, Forcet, Formigran, Imigran, Imigrane, Imiject, Migranol, Migrastat, Migrex, Nograine, Sitran, Suma, Sumagen, Sumamigren, Sumatab, Sumatran, Sumetrin, Sumigran, Suminat, Sumitran, Sumitrex, Suvalan, Zumo,

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Imiject nasal products are used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Imiject is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels around the brain, stopping pain signals from being sent to the brain, and blocking the release of natural substances that cause pain, nausea, and other symptoms of migraine. Imiject does not prevent migraine attacks or reduce the number of headaches you have.

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The outcome was favorable after a 14-day course with ciprofloxacin. We show here that the 8-kDa I2 protein is expressed at late times of infection, is tightly associated with membranes, and is encapsidated in mature virions. A Gas Chromatography-Mass Spectrometry approach was used to determine the volatile biochemical profiles of each line and after data curation and processing, discriminatory metabolites were putatively identified based on in-house and commercial spectral libraries. Kinetics of miR-122 expression in the liver during acute HCV infection.

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Our results reduced the linkage interval of previously reported cataract locus on chromosome 9, thus considerably reducing the number of candidate genes. Comparative Safety of Targeted Therapies for Metastatic Colorectal Cancer between Elderly and Younger Patients: a Study Using the International Pharmacovigilance Database. The exact pathogenesis of and the best therapeutic strategy for AESD are uncertain.

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The purpose of this study is to evaluate the usefulness of the design of experiments in the analysis of multiparametric problems related to the quality assurance in radiotherapy. Overexpression of Wnt1, Wnt3a or Wnt5a protein causes a dramatic increase in satellite-cell proliferation. A descriptive, cross sectional study was carried out in a tertiary eye care center which included 176 cases. In order to assess the quality, purity, and uniformity of commercial Radix Astragali, 44 samples were purchased from herbal stores in Hong Kong and New York City. In this paper, a conservative strategy that pushes the optimal design into the feasible region was used to address surrogate-modeling uncertainty.

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Differences in reproductive costs between male and female plants have been shown to foster sex-related variability in growth and C-storage patterns. Progress In Achieving Health Equity Requires Attention To Root Causes.

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Diffraction in the Fourier-transform infrared spectrometer based on step mirrors was analyzed in the present paper, and the influence of diffraction on the spectrum reconstruction with different width of step mirrors, wavelengths and distance was also discussed. Search time patterns provided evidence for lateral attention shifts only when participants performed the flanker task under an instruction assumed to widen the focus of attention, demonstrating that instruction-based control settings of an otherwise identical task can impact performance in an unrelated task.

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Eulogy of Professor Albert Claude, Nobel Prize in Medicine and Physiology in 1974 The hit rate of SSV, an individual short test, was too low for clinical use. Statin therapy prior to percutaneous coronary intervention (PCI) is associated with reduced mortality and periprocedural myocardial injury after PCI.

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These changes in nesting styles and behaviors thus may have played a role in the evolutionary success of maniraptorans (including birds). This issue should be addressed when analyzing cost data from interviews and when designing studies on health economy. Sequences flanking the EPL Alu family member stimulate its RNA polymerase III (Pol III) template activity in vitro. A total of 16 normal subjects (aged between eight and 57 years) were investigated on a 3.0 Tesla GE Signa system. To assess clinical and ultrasound morphologic features in 41 patients with scars resulting from moderate to severe acne and to determine whether correlation exists.

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Here, we evaluated Cox and logistic regression applied to cohort and case-cohort genetic association studies using simulated data and genetic data from the EPIC-CVD study. For male alcoholics who had sex with men, the focus should be on those who primarily socialize in bars. Mitochondria-Targeted Near-Infrared Fluorescent Off-On Probe for Selective Detection of Cysteine in Living Cells and in Vivo.

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In the backdrop the review highlighted the contribution of topological indices from different concepts in the HIV-1 drug research. While neutrophilic lung inflammation occurs during such infections, its role remains unclear. Microglial cells are the main innate immune cells of the complex cellular structure of the brain. Host defense peptides (HDPs), a class of conserved components of animal innate immune system, possess direct antimicrobial activities against invading pathogens and broadly participate in boosting and modulating host immune responses. Part II continues this research by delving deeper into the amino acid, fatty acid and mineral components.

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Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma. Surgical removal of primary or metastatic cancers may be curative and should be attempted wherever possible. During the 2009 influenza A (H1N1) pandemic, unusual influenza activity outside the typical winter season provided a unique opportunity to evaluate the association between influenza and pneumonia incidence.

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DW-MR imaging is preferred because of its ease of implementation and lack of need for an extrinsic contrast agent. Synthesis and characterization of nanoscale dendritic RGD clusters for potential applications in tissue engineering and drug delivery. Can myxosporean parasites compromise fish and amphibian reproduction?

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We chose endovascular therapy for treating the AAA rather than graft replacement because of the risk of infection by the colostomy orifice. The trp side chains are observed to adopt multiple packing arrangements with a freezing temperature below 273 K in the simulated system. A similar small perturbation of the structure of water was previously observed in the vicinity of water-soluble zwitterionic polymers and zwitterionic copolymer films using Raman and attenuated total reflection infrared spectroscopies, respectively. In order to provide a scientific basis for rational use of antibiotics, we studied and compared the therapeutic effects of step-down and step-up antibiotic treatment schemes in children with lobar pneumonia.

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Porcelain/alloy wettability can be used as a guide to improve the bonding property between dental porcelain and alloys. Computed tomographic images were used to determine the presence of hepatic steatosis. Comparison of various density functional methods for distinguishing stereoisomers based on computed (1)H or (13)C NMR chemical shifts using diastereomeric penam beta-lactams as a test set.

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Information on socio-demographic variables as well as awareness and practices regarding BPCR were collected through semi-structured interview. A number of studies have shown that tooth-like structures can be regenerated using induced pluripotent stem cells and mouse embryonic stem (mES) cells. Two immune-reactive signals (33 and 14 kDa) were detected in normal and tumor tissues from 19 patients. Nevertheless, strict dosimetric optimization is needed in order to further reduce the risk of late severe toxicity.

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Malaria and pregnancy in Cameroonian primigravidae: humoral and cellular immune responses to Plasmodium falciparum blood-stage antigens. Huh7 cells with stable knockdown of Rab1a exhibited reduced endocytic processing of ASOR. Autoantibodies against desmocollins in European patients with pemphigus.

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Although this research was set in England, the methodology may provide a useful template for other countries. Identification of Leptospira interrogans phospholipase C as a novel virulence factor responsible for intracellular free calcium ion elevation during macrophage death. The initial diagnosis and staging of cervical cancer has traditionally been achieved by history and physical examination and by use of selected imaging studies. This revised motivational view proposes that narcissistic dynamics can be preserved and articulated in exclusively motivational terms. Mutations in the mitochondrial genes as COX II, ATPase 6 and 8 play an important role and disrupts ATP production affecting the spermatogenesis and sperm motility.

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Xeroderma pigmentosum (XP) is a devastating disease due to severe defects in the repair of mutagenic DNA lesions introduced upon exposure to solar radiations. The CC chemokines tend to be involved in chronic inflammation, and recently we have cloned a fourth leukocyte receptor for this group of ligands. To detect the locality of the D-beta-Asp-containing protein, immunohistochemical staining using the antibody was carried out in ocular samples obtained from nine donors 18 to 88 years of age and two fetuses. Patient specific dosimetry for intensity-modulated radiotherapy delivered with first helical tomotherapy in India--our initial experience of 50 patients.

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Information uncovered in the literature review was interpreted in light of related pharmacoepidemiological and psychiatric literature. It has been recently revealed that sulfonic groups trigger apatite nucleation in a body environment. The results indicated the potential utility of the S/O nanodispersion as a novel vehicle for transcutaneous protein delivery. Influence of the Surface Roughness of Platinum Electrodes on the Calibration of the Electrochemical Quartz-Crystal Nanobalance.

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When the cutting current is used, prostatic tissue can be removed safely and effectively. Sub-regions were defined on the standard brain surface based on macro- and micro-structural information. As part of this work, a mathematical model was developed and confirmed the trend in the reflectance signal due to changes in surface scattering and subsurface birefringence. The incineration residues can then be formed into granules that can be used as an efficient absorbent for fluids spilled onto solid surfaces.

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Therefore, we sought to determine whether MEK1 and ERK activities also stimulate IL-2 gene transcription. To determine the most effective antibiotic treatment strategy, it is essential to have a diagnostic test that can correctly measure the true status of ocular Chlamydia trachomatis infection in individuals, particularly after treatment. Over the years, the clinimetric properties of the NCS and its revised version (NCS-R) have been assessed, but no formal summary of these properties has been made.

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Polymerization of the MMA can be accelerated or slowed down by changing polymerization temperature and initiator concentration. Percutaneous transhepatic drainage (PTD) of the liver abscess was performed and antibiotic treatment was initiated. Compared with the other lactobacilli and to the drug Hu-Gan-Pian, there is a high chance that L.

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Analysis of NADPH supply during xylitol production by engineered Escherichia coli. Although a plethora of tools are available for making pathogenicity predictions over a genome-wide scale, previous tools fail to perform in a robust manner when applied to KCNQ1. CSF-ADA 10 U/l is the standard cut off value that is used for differentiation between Tuberculous (TBM) and Non-Tuberculous Meningitis (non-TBM). Prospective study randomized 141 patients age 50 years and older with a fragility fracture into 3 groups for comparison.

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Malaria parasites (genus Plasmodium) infect all classes of terrestrial vertebrates and display host specificity in their infections. Prolonged inflammation might have caused extensive corrosion of titanium in the present case.

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The peptidyl-prolyl isomerase Pin1 is frequently up-regulated in human cancers in which Rel/nuclear factor-kappaB (NF-kappaB) is constitutively activated, but its role in these cancers remains to be determined, and evidence is still lacking to show that Pin1 contributes to cell transformation by Rel/NF-kappaB. It was significantly enhanced at pH 9 compared to those at pH 6 and 7 with MP UV irradiation, while it was slightly enhanced at pH 9 with LP UV. High respiratory quotient is associated with increases in body weight and fat mass in young adults. We address this issue by investigating CCFs between spherical colloidal particles around the critical point of a binary solvent through a combination of experiments, previous Ising Monte Carlo simulation results and field-theoretical methods.

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Some properties and applications of thin self-supporting polymer membranes. The majority of obesity in adulthood has its origins in childhood which makes obesity a pediatric concern and the period when interventions should be done. For larger IS, the retention is depending on the water content and the fluid velocity.

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A 74-year-old woman developed bilateral uveitis with high Epstein-Barr virus (EBV) DNA load in the vitreous fluid without lymphoma cells. Pharmaceuticals and their active metabolites are one of the significantly emerging environmental toxicants.

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Ninety-three patients had spinal fusion (case group), and 150 patients were without spinal fusion (controls). In this paper, we present a fusion approach to solve the nonrigid shape recovery problem, which takes advantage of both the appearance information and the local features. The present study reports the ability of both Cr(VI)-sensitive and tolerant Dyctiosphaerium chlorelloides strains to live in aqueous solutions highly contaminated with hexavalent chromium under varying ranges of pH, by the determination of chromium toxic effects on these strains.

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To determine how many days of pedometer monitoring are necessary to estimate monthly ambulatory activity in adults. We show that two closely related LIM homeodomain proteins, Lhx2 and Lhx9, are expressed by a set of commissural relay neurons (dI1c neurons) and are required for the dI1c axon projection.

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This led to decreased cerebral blood flow in the left hemisphere of his brain. Meta-analysis on the effect of dopexamine on in-hospital mortality. Minimal model for zero-inertia instabilities in shear-dominated non-Newtonian flows. Over time, this patient developed new sclerochoroidal calcifications and enlargement of preexisting calcifications.

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LP was associated with an increased rate of AIDS/deaths, particularly in the first year after HIV diagnosis, with significant variation across Europe. Although some pioneer studies on the use of cell therapy for the treatment of stroke have been reported, certain problems still remain unsolved.

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It describes laparoscopic Roux-en-Y gastric bypass surgery, an invasive intervention for the management of obesity. Of the 12 joints imaged with SPECT, PET image quality/resolution was superior in 11 and inferior in one. Model performance was assessed using the Hosmer-Lemeshow C statistic for calibration, and the area under the receiver operating characteristic curve for discrimination. We do not find protein expression of the transcription factor Oct-2, implicated by others as an alpha gene repressor. Parallel studies were undertaken in an animal model of hypoxia-induced pulmonary hypertension (PH).

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By examining these problems from an engineering perspective, the authors hope to clarify what can and cannot be prevented by understanding and manipulating the fluid dynamics of ultrafiltration. Acquired intracranial arterial aneurysm and stroke after vessel dissection in a child with coarctation of the aorta. Both parameters and the extent of aging are related to the free volume available for the different types of polymers. All hydroxyapatites elicited TNF-alpha release from the NR8383 cells, but with significantly lower potency than DQ12 quartz and LPS.

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Unsettled questions about their therapeutic use include whether dose dependence can be shown for the clinical benefits of inhaled corticosteroids, whether delay in initiating inhaled corticosteroid treatment reduces the benefit that can be achieved, and whether the benefits of even prolonged therapy are short-lasting. To determine the frequency and validity of exceptions to quality measures and to test a system for classifying the reasons for these exceptions. BRCA1 regulates progesterone receptors A and B protein expressions in breast cancer cells in vitro The method may be used for quality control or to assess the level of asymmetry of the material in terms of its acoustic properties.

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These observations open the way for the creation of biotherapeutics with significantly improved pharmacokinetics. In contrast, numerosity-sensitive ERP activity at occipito-parietal channels later in the time course (210-230ms) did not show polarity inversion, indicating a subsequent processing stage in the dorsal stream.

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The side chain of Arg24 in DHFRL1 can extend deeply into the binding sites of DHF and NADPH, and disturb the DHF binding by steric effect, which rarely happens in human DHFR and R24W DHFRL1 mutant. Therefore, we surveyed pediatric urologists to determine their current practices and preferences of modalities of voiding cystography. As one of the measures to improve the environment in an automobile, malodor caused by the automobile air-conditioning system evaporator was evaluated and analyzed using laboratory-scale test cooling bench.

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The results of our studies suggest that SFRP1 may be involved in the development of periodontitis, since inhibiting SFRP1 resulted in reduced periodontal breakdown. Alignment of 3 virus sequences from different parts of Iran revealed that they are identical suggesting that the circulating viruses were most likely the same in this period. We used a 2-arm comparative effectiveness trial involving 134 African grofenac tablets android American women aged 18 to 34 years to compare the effectiveness of the Centers for Disease Control and Prevention-defined evidence-based Sisters Informing Sisters about Topics on AIDS (SISTA) HIV intervention with P4 for Women, an adapted faith-based version of SISTA. In this paper, I document, using a combination of mark/recapture techniques and histocompatibility assays, dispersal distance of the planktonic larvae of the sessile, colonial sea squirt Botryllus schlosseri.

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Mutation spectra of chemical fractions of a complex mixture: role of nitroarenes in the mutagenic specificity of municipal waste incinerator dorit chrysler halcion generic emissions. The role of acetylation in the genotoxicity of the heterocyclic amine, batracylin, was evaluated in Salmonella typhimurium strains expressing various levels of N- and O-acetyltransferase activity. COPD is increasingly considered a multisystem disease characterized by both pulmonary and systemic inflammation.

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